Only around a fifth of women at higher risk of developing breast cancer think they need to take a drug proven to help prevent the disease, according to new research funded by Cancer Research UK and published today Monday in Clinical Breast Cancer. The researchers, led by a team from the University of Leeds, asked more than healthy women at a higher-risk of breast cancer, from 20 centres across England, whether they thought they needed to take tamoxifen and their concerns about medication. In a follow-up questionnaire, answered by of the women, researchers found that fewer than 15 per cent were taking tamoxifen despite having discussed preventive therapy with a healthcare professional.
The current challenge is to find new agents with fewer side effects and to find agents that are specifically suitable for premenopausal women with ER-negative breast cancer. SERMs are interesting agents for the prevention of breast cancer, but longer follow-up is needed for some of them for a complete risk—benefit profile of these drugs. Aromatase inhibitors have emerged as new drugs in the prevention setting for postmenopausal women.
But there is a lot of good news about breast cancer these days. Treatments keep getting better, and we know more than ever about ways to prevent the disease. These eight simple steps can help lower the risk of breast cancer.
Assembly version: 1. This version of this topic is currently archived and inactive. It should be used for historical purposes only. The USPSTF recommends that clinicians engage in shared, informed decision making with women who are at increased risk for breast cancer about medications to reduce their risk.
Tamoxifen and raloxifene have been shown to reduce the risk breast cancer, but they can have their own risks and side effects. Both of these drugs are selective estrogen receptor modulators SERMs. This means that they act against or block estrogen a female hormone in some tissues of the body, but act like estrogen in others.
Skip to Content. Use the menu to see other pages. Although risk factors often influence the development of cancer, most do not directly cause cancer.
Back to Cancer. Current guidelines recommend that women thought to be at increased risk of developing breast cancer because they have a family history of the condition should be offered a drug called tamoxifen. Tamoxifen can reduce this risk, but the drug, which women usually have to take every day for 5 years, can cause side effects such as hot flushes, tiredness and nausea.
These medications act only to reduce the risk of a specific type of breast cancer called estrogen receptor-positive breast cancer. This type of breast cancer accounts for about two-thirds of all breast cancers. Most breast cancer cells respond to hormones, specifically estrogen or progesterone. These hormones circulate in the blood.
In March,a group of breast cancer experts met to develop a consensus statement on breast cancer prevention, with a focus on medical and therapeutic interventions. We present the conclusions in this Review. First we agreed that the term chemoprevention is inappropriate and suggested that the term preventive therapy better represents this feature of management.
Belief among some women with family history of cancer suggest it is 'written in the stars' and side effects of tamoxifen not worth small risk reduction. Breast cancer drug tamoxifen has been recommended since for women with a high risk of developing breast cancer because of their family history, and can cut their chances of ever developing cancer by a third. I would be happy to start taking it, but yes, I do look at the side effects.