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Diet, obesity, and risk of fatal prostate cancer. Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. We also discuss some of the sequelae of obesity and their relationships with prostate cancer, including alterations in insulin, the insulin-like growth factor axis, and leptin levels; insulin resistance; and diabetes. The prostate: a target for carcinogenicity of 2-aminomethylphenylimidazo[4,5-b]pyridine PhIP derived from cooked foods. The link between leptin and body weight was further demonstrated when a double-blind, randomized, controlled trial found that administration of recombinant leptin resulted in greater weight loss than did placebo among obese patients. In this study, obesity was not related to prostate cancer risk among older men.

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In general, increased numbers of adipocytes are associated with higher serum leptin levels.

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Harmoni. Age: 31.
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Prevalence and trends in obesity among US adults, — IGF Axis IGF-I is a peptide growth factor and a potent mitogen for the growth of androgen-responsive and androgen-independent human prostate cancer cell lines. Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence. A prospective study of dietary fat and risk of prostate cancer. Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study.

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