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Metaplastic breast cancer MBC is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatment options are available for MBC, as it has consistently shown a suboptimal response to standard chemotherapy regimens. These characteristics result in a worse overall prognosis for patients with MBC compared to those with standard invasive breast cancer.
Metaplastic carcinomas of breast are uncommon, representing 0. We are reporting two cases of metaplastic carcinoma breast, one revealing rhabdomyoblastic and spindle cell differentiation and other revealing osteoclast like giant cells. Both were estrogen receptor, progesterone receptor and Her2u negative on immunohistochemistry.
Spindle cell carcinoma of the breast is a rare sub-type of breast cancerthat falls within the general category of metaplastic breast carcinoma. There are really no clinical symptoms that would distinguish this particular cancer from other types of breast cancers. Thus diagnosis is dependent on the histological evaluation of tissue samples from a biopsy. As the name suggests, these type of breast tumors tend to have spindle shape cells along with some other component of either.
Metaplastic breast carcinoma MBC is a rare heterogeneous group of primary breast malignancies, with low hormone receptor expression and poor outcomes. To date, no prognostic markers for this tumor have been validated. The current study was undertaken to evaluate the clinicopathologic characteristics, the response to various therapeutic regimens and the prognosis of MBCs in a large cohort of patients from Tianjin Medical University Cancer Hospital in China.
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Metaplastic breast carcinomas MBC are rare primary breast malignancies characterized by the co-existence of carcinoma with non-epithelial cellular elements. They can be classified as monophasic spindle cell sarcomatoid carcinoma, biphasic carcinosarcoma, adenocarcinoma with divergent stromal differentiation osseous, chondroid and rarely rhabdoid as well as adenosquamous and pure squamous cell carcinomas. Nearly all reports portrait women in their forties or older, yet younger affected females in their twenties have been reported.
Follow us:. Metaplastic Carcinoma. In metaplastic carcinomas, the predominant cell type is other than epithelialusually a mesenchymal element.
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It differs from the more common kinds of breast cancer in both its makeup and in the way it behaves. Like invasive ductal cancer, metaplastic breast cancer begins in the milk duct of the breast before spreading to the tissue around the duct. What makes a metaplastic tumor different is the kinds of cells that make up the tumor.